| | | | March 2023 Clinical Update: NCCN Guidelines for Treatment of Breast Cancer
| | The National Comprehensive Cancer Network (NCCN) Guidelines for Breast Cancer focus on screening, diagnosis, staging, treatment, and management. All breast cancer therapy regimens were categorized to provide guidance on treatment selection by considering the efficacy, safety, evidence, and other factors that play a role in treatment selection. These factors include comorbidities, nature of the disease, access to agents and hereditary genetic risk.
These updated guidelines include criteria for further genetic risk evaluation using a germline cancer panel for hereditary breast cancer syndromes: - Family history of known pathogenic variations or cancer,
- Diagnosed before the age of 45,
- Tumors with certain histological characteristics and location.
The panels are recommended to contain ATM, BRCA1, BRCA2, CHEK2, PALB2, PTEN, RAD50, RAD51C, RAD51D, STK11, and TP53.
Genetics Institute of America’s GIAnomics™ Oncology Germline Panel includes all the recommended predisposition genes for breast cancer. GIA is committed to exceeding the standards put forth by prestigious organizations, like NCCN, and ensuring that the panels we offer support your medical needs and your patient’s health and safety. | | | | Have you Seen This?:
PARPi Beyond BRCA “A mounting body of evidence now indicates that PARP inhibitors (PARPi) have the potential to be used as a foundation for both monotherapy and combination strategies across a wide spectrum of molecular backgrounds and tumor types,” not just with BRCA-positive patients.1 Read more >> | | | |
It's All in the Genes:
Germline Variants Affect Clinical Subtypes of Breast Cancer Clinical subtypes determined by the estrogen receptor (ER), progesterone receptor (PR), and HER2 tumor markers are commonly used to determine treatment strategy and disease prognosis. Read more >>
| | | | Changing Corporate Culture: CityHouse 5K and Providing Care for Single Mothers Since being established in 2014, CityHouse of Delray Beach, Florida provides long-term, transformational assistance to mothers and their children. They help single mothers in need have better opportunities to develop healthy lifestyles, which enables them to provide sustainable, loving and proper care for their children. Read more >> | | | | | | | | Enroll your Practice in GH-101! | | Genetics Institute of America is actively recruiting practices to join our study, GH-101! The objective of this study is to take an integrative approach to the fields of pharmacogenomics, cancer genomics, mRNA microarrays and nutrigenomics by identifying DNA and RNA variants in persons with chronic disease. We are looking for Physicians and Physician Groups that currently treat patients with a chronic disease including: cancer, cardiac conditions, diabetes, kidney disease, PTSD. Getting your practice involved is easy and not only gets patients the individualized health information they need but allows your practice to be on the cutting edge of genetic research. | | | | | | Thank you for the trust and confidence you have placed in our team here at the Genetics Institute of America. This monthly newsletter is our primary method of communicating to you important information about our testing and assays, general information about the Genetics Institute, as well as information impacting patient care and safety. If you would like to have another person in your practice receive these updates, please forward this to them so that they can subscribe.
 Ana Perez-Miranda, PhD, MDxT (AAB), MB (ASCP) Laboratory Manager and Molecular Diagnostics Supervisor Genetics Institute of America | | | | | | | | | | GIA Lab News is an educational service of Genetics Institute of America.
Genetics Institute of America is a national laboratory dedicated to heightening the awareness of early intervention and genetic screening to promote the longevity and quality of life outcomes. Our determination and research allow us to provide next generation DNA sequencing to deliver customized testing for identified genetic related cancers and other diseases. | | | | | | 4733 W. Atlantic Ave, Suite C16 Delray Beach, FL 33445 Phone: (833) 4GENLAB or (833) 443-6522 HIPAA Fax: (561) 354-5369
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